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Cabotegravir-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cabotegravir-d5图片
包装:1mg
规格:98%
市场价:6297元
分子量:410.4

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21962
CAS:N/A
分子式:C19H12D5F2N3O5
分子量:410.4
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cabotegravir-d5is intended for use as an internal standard for the quantification of cabotegravir by GC- or LC-MS. Cabotegravir is an inhibitor of HIV-1 integrase (IC50= 3 nM in a strand transfer assay).1It inhibits HIV replication in MT-4 cells and peripheral blood mononuclear cells (PBMCs; IC50s = 1.3 and 0.2 nM, respectively). Cabotegravir (50 mg/kg) is protective against simian/human immunodeficiency virus (SHIV) infection in macaques when administered 1 week prior to viral challenge.2


1.Johns, B.A., Kawasuji, T., Weatherhead, J.G., et al.Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).J. Med. Chem.56(14)5901-5916(2013) 2.Andrews, C.D., Spreen, W.R., Mohri, H., et al.Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virusScience343(6175)1151-1154(2014)