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Vatalanib succinate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vatalanib succinate图片
规格:98%
分子量:464.9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent VEGFR inhibitor; also aromatase inhibitor
货号:ajcx27176
CAS:212142-18-2
分子式:C20H15ClN4.C4H6O4
分子量:464.9
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent VEGFR inhibitor (IC50 values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC50 = 50 nM). Orally available.


Banerjee et al (2009) The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase. Cancer Res. 69 4716 PMID:19435899 |Wood et al (2000) PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60 2178 PMID:10786682 |Bold et al (2000) New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J.Med.Chem. 43 2310 PMID:10956229