rac-CCT 250863 (compound rac-21) 是一种选择性和可逆的 NEK 2 抑制剂,IC50 为 0.073 μM。 rac-CCT 250863 表现出良好的诱导细胞周期停滞的作用,并且还可以在细胞中进行抗增殖(Pomalidomide 敏感/抗性)。 rac-CCT 250863 与 Pomalidomide 结合时可诱导细胞凋亡。
货号:ajcx26850
CAS:1364269-06-6
分子式:C24H25F3N4O2S
分子量:490.54
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:
现货Background:
Potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228 PMID:22404346