A selenium-containing amino acid
货号:ajcx24832
CAS:863394-07-4
分子式:C4H9NO2Se •HCl
分子量：218.6
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Se-Methylselenocysteine is a selenium-containing amino acid that has been found inAlliumand has antioxidative and anticancer augmenting activities.^1,2Se-Methylselenocysteine (0.01-10 µM) preventstert-butyl hydroperoxide-induced increases in malondialdehyde (MDA) levels and glutathione reductase and glutathione peroxidase (GPX) activity, as well as decreases in glutathione (GSH) levels, in HepG2 cells.¹It has an additive effect on irinotecan-induced tumor growth reduction in a FaDu mouse xenograft model when administered at a dose of 5 µg/animal per day.²

1.Cuello, S., Ramos, S., Mateos, R., et al.Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxideAnal. Bioanal. Chem.389(7-8)2167-2178(2007) 2.Azrak, R.G., Cao, S., Pendyala, L., et al.Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependentBiochem. Pharmacol.73(9)1280-1287(2007)