| 规格: | 98% |
| 分子量: | 352.4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
Efinaconazole-d4is intended for use as an internal standard for the quantification of efinaconazole by GC- or LC-MS. Efinaconazole is a broad-spectrum triazole antifungal agent with activity againstAcremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton,andTrichosporon.1It inhibits the growth ofT. rubrumandT. mentagrophytesclinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and ofC. albicansisolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane.2It inhibits ergosterol biosynthesis inT. mentagrophytesandC. albicanswith IC50values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.
1.Jo Siu, W.J., Tatsumi, Y., Senda, H., et al.Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosisAntimicrob. Agents Chemother.57(4)1610-1616(2013) 2.Tatsumi, Y., Nagashima, M., Shibanushi, T., et al.Mechanism of action of efinaconazole, a novel triazole antifungal agentAntimicrob. Agents Chemother.57(5)2405-2409(2013)
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