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rac-Tolterodine-d14(tartrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
rac-Tolterodine-d14(tartrate)图片
包装:1mg
规格:98%
市场价:3185元
分子量:489.7

产品介绍
C22H17D14NO•C4H6O6
货号:ajcx24124
CAS:N/A
分子式:C22H17D14NO•C4H6O6
分子量:489.7
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

rac-Tolterodine-d14is intended for use as an internal standard for the quantification of tolterodine by GC- or LC-MS. Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5receptors, respectively).1It reduces intracellular calcium mobilization induced by carbachol in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively).2Tolterodine inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively).3Formulations containing tolterodine have been used in the treatment of overactive bladder.


1.Jones, L.H., Randall, A., Napier, C., et al.Design and synthesis of a fluorescent muscarinic antagonistBioorg. Med. Chem. Lett.18(2)825-827(2008) 2.Kobayashi, S., Ikeda, K., and Miyata, K.Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: A Ca2+ mobilization study in monkey cellsLife Sci.74(7)843-853(2004) 3.McNamara, A., Pulido-Rios, M.T., Sweazey, S., et al.Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonistEur. J. Pharmacol.605(1-3)145-152(2009)