A macrolide polyketide with antimycobacterial and anticancer activities
货号:ajcx23852
CAS:2209112-96-7
分子式:C60H98O23
分子量：1187.4
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Amycolatopsin A is a macrolide polyketide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.¹It is active againstM. bovisandM. tuberculosis(IC₅₀s = 0.4 and 4.4 µM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC₅₀s = >30 µM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC₅₀s = 0.08 and 1.2 µM, respectively).

1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)