A neuropeptide with diverse biological activities
货号:ajcx22714
CAS:N/A
分子式:C24H18D5NO2
分子量：362.5
溶解度:DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml,DMSO: 20 mg/ml,Ethanol: 15 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JWH 018 N-(5-hydroxypentyl) metabolite-d₅contains five deuterium atoms at the 2', 4', 5', 6', and 7' positions. It is intended for use as an internal standard for the quantification of JWH 018 N-(5-hydroxypentyl) metabolite by GC-or LC-mass spectrometry (MS). JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor, derived from the aminoalkylindole WIN 55,212-2. The K_ivalues for binding central cannabinoid (CB₁) and CB₂receptors are 9.0 and 2.94 nM, respectively, for a CB₁:CB₂ratio of 3.06.¹JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-(5-hydroxypentyl) metabolite is a major urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain. In urine samples, this metabolite is almost completely glucuronidated.²

1.Aung, M.M., Griffin, G., Huffman, J.W., et al.Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor bindingDrug Alcohol Depend.60(2)133-140(2000) 2.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)