A neuropeptide with diverse biological activities
货号:ajcx22210
CAS:N/A
分子式:C31H54N7O17P3S.XH2O
分子量：921.8
溶解度:Water: 20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Decanoyl-coenzyme A (CoA) is a thioester of decanoic acid and CoA .¹It inhibits the activity of citrate synthase (CS) and glutamate dehydrogenase (GDH) in mitochondria isolated from rat brain (IC₅₀s = 437 and 420 µM, respectively).²Decanoyl-CoA also binds the fatty acid metabolism regulator protein (FadR) promoter inE. coli(K_i= 2 µM).³It is produced during isomerase-dependent β-oxidation of oleic acid in isolated rat heart mitochondria.⁴

1.Gregersen, N., KØlvraa, S., and Mortensen, P.B.Acyl-CoA: Glycine N-acyltransferase: In vitro studies on the glycine conjugation of straight- and branched-chained acyl-CoA esters in human liverBiochem. Med. Metab. Biol.35(2)210-218(1986) 2.Lai, J.C., Lian, B.B., Zhai, S., et al.Brain mitochondrial citrate synthase and glutamate dehydrogenase: Differential inhibition by fatty acyl coenzyme A derivativesMetab. Brain Dis.9(2)143-152(1994) 3.DiRusso, C.C., Heimert, T.L., and Metzger, A.K.Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AJ. Biol. Chem.267(12)8685-8691(1992) 4.Ren, Y., and Schulz, H.Metabolic functions of the two pathways of oleate β-oxidation double bond metabolism during the β-oxidation of oleic acid in rat heart mitochondriaJ. Biol. Chem.278(1)111-116(2003)