An internal standard for the quantification of 8iso prostaglandin F2α
货号:ajcx21540
CAS:211105-40-7
分子式:C20H30D4O5
分子量：358.5
溶解度:10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

8-isoPGF_2α-d₄contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-isoPGF_2αby GC-or LC-mass spectrometry. 8-isoProstaglandin F_2α(8-isoPGF_2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.^1,2,3It circulates in human plasma in two distinct forms -esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-isoPGF_2αlevel of about 150 pg/ml in normal volunteers. In normal human urine, 8-isoPGF_2αlevels are about 180-200 pg/mg of creatinine.^1,28-isoPGF_2αis a weak TP receptor agonist in vascular smooth muscle.⁴Conversely, 8-isoPGF_2αinhibits platelet aggregation induced by U-46619 (10^-6M) and I-BOP (3 x 10^-7M) with IC₅₀values of 1.6 x 10^-6M and 1.8 x 10^-6M, respectively.³

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