RBN-2397 是一种强效的，跨物种的，且具有口服活性的 NAD+ 竞争性 PARP7 抑制剂，IC50 值小于 3 nM。RBN-2397 有选择性地结合 PARP7 (Kd=0.001 μM) 并可以恢复干扰素 I 型信号转导。RBN-2397 有潜力用于研究晚期或转移性实体肿瘤。
货号:ajcx16750
CAS:2381037-82-5
分子式:C20H23F6N7O3
分子量：523.43
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores interferon (Type I) signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors[1][2].

[1]. RBN-2397-Inhibiting PARP7, a Key monoPARP Cancer Dependency [2]. Melissa Vasbinder, et al. RBN-2397: A First-in-Class PARP7 Inhibitor Targetinga Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways.