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PF-06882961
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06882961图片
规格:98%
分子量:555.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
PF-06882961 是一种有效的,具有口服活性的胰高血糖素样肽-1 受体 (GLP-1R) 激动剂。
货号:ajcx15448
CAS:2230198-02-2
分子式:C31H30FN5O4
分子量:555.6
溶解度:DMSO: 125 mg/mL (224.98 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PF-06882961 is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor (GLP-1R)[1][2].


PF-06882961 (3-240 mg per day) shows mild to moderate damage to the heart, moderate to severe effects on the thymus gland (which helps with managing infection), mild to moderate stomach ulcers at the highest dose level given in the rat[3].PF-06882961 (3-240 mg per day) results one death in an earlier 2-week monkey study at the highest PF-06882961 dose given in that study. No deaths are seen in the 6-week monkey study or any other monkey studies at any of the doses given[3]. Animal Model: 4-week rat[3]

[1]. 20th SCI/RSC Medicinal Chemistry Symposium. [2]. MÉndez M, et al. Design, Synthesis, and Pharmacological Evaluation of Potent Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor (GLP-1R). J Med Chem. 2019 Oct 23. [3]. POSSIBLE SIDE EFFECTS AND RISKS OF THE STUDY DRUG AND PROCEDURES.