CTPI-2 是第三代线粒体柠檬酸盐载体 SLC25A1 抑制剂，KD 为 3.5 μM。
货号:ajcx11594
CAS:68003-38-3
分子式:C13H9CIN2O6S
分子量：356.74
溶解度:DMSO:125 mg/mL(350.40 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and sphere-forming capacity of the indicated tumor cells relative to monolayer cultures, demonstrates broad activity on lung CSCs, inhibiting mitochondrial respiratory activity, self-renewal and matrix invasion; inhibits tumor growth in in vivo models of NSCLC.

参考文献:
[1]. Fernandez HR, et al. Cell Death Differ. 2018 Jul;25(7):1239-1258.