规格: | 98% |
分子量: | 260.1 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Background:
Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused byB. cinerea,S. sclerotiorum, andMoniliniaspecies in grapes, fruits, vegetables, ornamental plants, and turfgrass.1Metabolites of vinclozolin, M1and M2, are effective antagonists of the androgen receptor in rats exhibiting Kivalues of 92 and 9.7 µM respectively.2In fathead minnow, M1and M2failed to compete for high-
1.Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al.Biotransformation of vinclozolin by the fungus Cunninghemella elegansJ. Agric. Food Chem.48(12)6138-6148(2000) 2.Kelce, W.R., Monosson, E., Gamcsik, M.P., et al.Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolitesToxicol. Appl. Pharmacol.126(2)276-285(1994) 3.Makynen, E.A., Kahl, M.D., Jensen, K.M., et al.Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnowAquatic Toxicology48461-475(2000)