A neuropeptide with diverse biological activities
货号:ajcx23102
CAS:N/A
分子式:C10H14D3NO3
分子量：202.3
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-hexanoyl-L-Homoserine lactone-d₃(C₆-HSL-d₃) contains three deuterium atoms at the C-6 position. It is intended for use as an internal standard for the quantification of C₆-HSL by GC-or LC-mass spectrometry. Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. C₆-HSL is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism.¹The diverse applications of this molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention, and septicemia in fish.^{2,3,4,5,6,7,8}

1.Gould, T.A., Herman, J., Krank, J., et al.Specificity of acyl-homoserine lactone syntheses examined by mass spectrometryJ. Bacteriol.188(2)773-783(2006) 2.Morohoshi, T., Inaba, T., Kato, N., et al.Identification of quorum-sensing signal molecules and the LuxRI homologs in fish pathogen edwardsiella tardaJournal of Bioscience and Bioengineering98(4)274-281(2004) 3.Ulrich, R.L., Hines, H.B., Parthasarathy, N., et al.Mutational analysis and biochemical characterization of the bukholderia thailandensis DW503 quorum-sensing networkJournal of Bacteriology186(13)4350-4360(2004) 4.Wang, L.H., Weng, L.X., Dong, Y.H., et al.Specificity and enzyme kinetics of the quorum-quenching N-acyl homoserine lactone lactonase (AHL-lactonase)The Journal of Biological Chemisty279(14)13645-13651(2004) 5.Yates, E.A., Philipp, B., Buckley, C., et al.N-acylhomoserine lactones undergo lactonolysis in a pH-temperature-, and acyl chain length-dependent manner during growth of yersinia pseudotuberculosis and pseudomonas aeruginosaInfection and Immunity70(10)5635-5646(2002) 6.Luo, Z.Q., Su, S., and Farrand, S.K.In situ activation of the quorum-sensing transcription factor TraR by cognate and noncognate acyl-homoserine lactone ligands: Kinetics and consequencesJournal of Bacteriology186(19)5665-5672(2003) 7.Christensen, A.B., Riedel, K., Eberl, L., et al.Quorum-sensing-directed protein expression in serratia proteamaculans B5aMicrobiology149471-483(2003) 8.Chambers, C.E., Visser, M.B., Schwab, U., et al.Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patientsFEMS Microbiology Letters244297-304(2005)