A fungal metabolite with anticancer and antimicrobial activities
货号:ajcx23000
CAS:955083-90-6
分子式:C26H37NO2
分子量：395.6
溶解度:DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Myceliothermophin E is a polyketide-amino acid hybrid fungal metabolite that has been found inT. thermophilusand has anticancer and antimicrobial activities.^1,2It is cytotoxic to DLD-1, Hep3B, HepG2, and HGC-27 cancer cells (IC₅₀s = 0.32, 0.42, 0.26, and 0.08 μg/ml, respectively).¹Myceliothermophin E is active against methicillin-resistant, but not -sensitive,S. aureus(MICs = 15.8 and >100 μM, respectively).²

1.Gao, Y.-L., Zhang, M.-L., Wang, X., et al.Isolation and characterization of a new cytotoxic polyketide-amino acid hybrid from Thermothelomyces thermophilus ATCC 42464Nat. Prod. Res.Epub ahead of print(2019) 2.Wang, X., Zhao, L., Liu, C., et al.New tetramic acids comprising of decalin and pyridones from Chaetomium olivaceum SD-80A with antimicrobial activityFront. Microbiol.102958(2020)