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Diosmetin-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diosmetin-d3图片
规格:98%
分子量:303.3
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Diosmetin-d3 是氘标记的 Diosmetin。 Diosmetin 是一种天然类黄酮,可抑制人 CYP1A 酶活性,在 HepG2 细胞中的 IC50 为 40 μM。
货号:ajcx22302
CAS:1189728-54-8
分子式:C16H9D3O6
分子量:303.3
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Diosmetin-d3is intended for use as an internal standard for the quantification of diosmetin by GC- or LC-MS. Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.1,2,3,4It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively).1Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH in a concentration-dependent manner.2It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day.3Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.4


1.Androutsopoulos, V.P., Papakyriakou, A., Vourloumis, D., et al.Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoidsBioorg. Med. Chem.19(9)2842-2849(2011) 2.Liao, W., Ning, Z., Chen, L., et al.Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generationJ. Agric. Food Chem.62(34)8648-8654(2014) 3.Choi, J., Lee, D.H., Park, S.Y., et al.Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancerBiomed. Pharmacother.117109091(2019) 4.Ge, A., Liu, Y., Zeng, X., et al.Effect of diosmetin on airway remodeling in a murine model of chronic asthmaActa Biochim. Biophys. Sin. (Shanghai)47(8)604-611(2015)