NMDARantagonist1是一种有效且口服生物可利用的，NR2B选择性的NMDAR拮抗剂。
货号:ajcx13412
CAS:2220162-06-9
分子式:C20H20BrN3O2
分子量：414.3
溶解度:DMSO : 5 mg/mL (12.07 mM);H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].

NMDAR antagonist 1 (Compound 5q) exhibits excellent neuroprotective activity[1]. NMDAR antagonist 1 can attenuate Ca2+ influx induced by NMDA[1].NMDAR antagonist 1 can suppress the NR2B up-regulation and increase p-ERK1/2 expression[1].NMDAR antagonist 1 inhibits SH-SY5Y cells with cell viabilities of 75.8%, 80.0%, 84.4%, and 78.6% at 0.1 µM 1 µM 10 µM 100 µM, respectively[1].

[1]. Zhang L, et al. Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. Eur J Med Chem. 2018 May 10;151:27-38.