SM-433 hydrochlorid 是一种 Smac 模拟物，是一种凋亡抑制蛋白 (IAPs) 的抑制剂发挥作用。SM-433 hydrochlorid 表现出强结合亲和力 XIAP BIR3 蛋白，IC50<1 μm (详细信息来自专利 wo2008128171a2)。
货号:ajcx36208
CAS:N/A
分子式:C32H44ClN5O4
分子量：598.18
溶解度:DMSO : 180 mg/mL (300.91 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2)[1].

SM-433 hydrochlorid exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].

[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.