An internal standard for the quantification of ganglioside GD3
货号:ajcx26532
CAS:2692624-24-9
分子式:C70H120D3N3O29 • 2NH4
分子量：1509.8
溶解度:Chloroform:Methanol:Water (2:1:0.1): Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C18 Ganglioside G_D3-d₃is intended for use as an internal standard in the quantification of ganglioside G_D3by GC- or LC-MS. Ganglioside G_D3is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.¹Furthermore, the intracellular accumulation of ganglioside G_D3can contribute to mitochondrial damage, a crucial event during apoptosis.²Ganglioside G_D3has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.^1,3[Matreya, LLC. Catalog No. 2054]

1.Hamamura, K., Furukawa, K., Hayashi, T., et al.Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cellsProc. Natl. Acad. Sci. USA102(31)11041-11046(2005) 2.De Maria, R., Lenti, L., Malisan, F., et al.Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosisScience277(5332)1652-1655(1997) 3.Nicoll, G., Avril, T., Lock, K., et al.Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanismsEur. J. Immunol.33(6)1642-1648(2003)