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C18 Ganglioside GD3-d3(ammonium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C18 Ganglioside GD3-d3(ammonium salt)图片
包装:500ug
规格:98%
市场价:8163元
分子量:1509.8

产品介绍
An internal standard for the quantification of ganglioside GD3
货号:ajcx26532
CAS:2692624-24-9
分子式:C70H120D3N3O29 • 2NH4
分子量:1509.8
溶解度:Chloroform:Methanol:Water (2:1:0.1): Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

C18 Ganglioside GD3-d3is intended for use as an internal standard in the quantification of ganglioside GD3by GC- or LC-MS. Ganglioside GD3is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.1Furthermore, the intracellular accumulation of ganglioside GD3can contribute to mitochondrial damage, a crucial event during apoptosis.2Ganglioside GD3has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.1,3[Matreya, LLC. Catalog No. 2054]

1.Hamamura, K., Furukawa, K., Hayashi, T., et al.Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cellsProc. Natl. Acad. Sci. USA102(31)11041-11046(2005) 2.De Maria, R., Lenti, L., Malisan, F., et al.Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosisScience277(5332)1652-1655(1997) 3.Nicoll, G., Avril, T., Lock, K., et al.Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanismsEur. J. Immunol.33(6)1642-1648(2003)