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Cyclo(RGDyK)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyclo(RGDyK)(trifluoroacetate salt)图片
规格:98%
分子量:619.7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A cyclic peptide ligand of αVβ3 integrin
货号:ajcx26362
CAS:N/A
分子式:C27H41N9O8 • XCF3COOH
分子量:619.7
溶解度:Ethanol: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Cyclo(RGDyK) is a cyclic peptide ligand of αVβ3 integrin (IC50= 37.5 nM) that contains the αVβ3 integrin-binding sequence arginine-glycine-aspartate (RGD).1It has been conjugated to radiolabels or fluorescent probes for the visualization of αVβ3-mediated neoangiogenesis or optical imaging of αVβ3-expressing tumors in live mice.2,1Cyclo(RGDyK) has also been conjugated to the DNA topoisomerase I inhibitor SN38 and an SN38-releasing trigger moiety to form a prodrug that targets cells overexpressing αVβ3 integrin and induces cytotoxicity in KB human cervical carcinoma cells.3


1.Chen, X., Conti, P.S., and Moats, R.A.In vivo near-infrared fluorescence imaging of integrin αvβ3 in brain tumor xenograftsCancer Res.64(21)8009-8014(2004) 2.van Hagen, P.M., Breeman, W.A., Bernard, H.F., et al.Evaluation of a radiolabelled cyclic DTPA-RGD analogue for tumour imaging and radionuclide therapyInt. J. Cancer90(4)186-198(2000) 3.Huang, B., Desai, A., Tang, S., et al.The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug releaseOrg. Lett.12(7)1384-1387(2010)