A metabolite of glycolithocholic acid
货号:ajcx26332
CAS:64936-82-9
分子式:C26H41NO7S • 2Na
分子量：557.7
溶解度:Methanol: slightly soluble,Water: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Glycolithocholic acid 3-sulfate is a metabolite of glycolithocholic acid .¹It is formed from glycolithocholic acid by hepatocytes.²Glycolithocholic acid 3-sulfate (240 µmol/kg) induces cholestasis and increases biliary cholesterol secretion in rats.³Serum glycolithocholic acid 3-sulfate levels are increased in patients with cirrhosis, hepatitis, or cholestasis.⁴

1.Palmer, R.H.The formation of bile acid sulfates: A new pathway of bile acid metabolism in humansProc. Natl. Acad. Sci. USA58(3)1047-1050(1967) 2.Kirkpatrick, R.B., and Belsaas, R.A.Formation and secretion of glycolithocholate-3-sulfate in primary hepatocyte culturesJ. Lipid Res.26(12)1431-1437(1985) 3.Yousef, I.M., Tuchweber, B., Vonk, R.J., et al.Lithocholate cholestasis-sulfated glycolithocholate-induced intrahepatic cholestasis in ratsGastroenterology80(2)233-241(1981) 4.Demers, L.M., and Hepner, G.W.Levels of immunoreactive glycine-conjugated bile acids in health and hepatobiliary diseaseAm. J. Clin. Pathol.66(5)831-839(1976)