您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 15-deoxy-&delta12,14-Prostaglandin J2-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
15-deoxy-&delta12,14-Prostaglandin J2-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
15-deoxy-&delta12,14-Prostaglandin J2-d4图片
规格:98%
分子量:320.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
An internal standard for the quantification of 15deoxyΔ12,14prostaglandin J2
货号:ajcx21130
CAS:1542166-82-4
分子式:C20H24D4O3
分子量:320.5
溶解度:DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12,
纯度:98%
存储:Store at -20°C
库存:现货

Background:

15-deoxy-δ12,14-PGJ2-d4contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 15-deoxy-δ12,14-PGJ2by GC-or LC-mass spectrometry. 15-deoxy-δ12,14-Prostaglandin J2(15-deoxy-δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-δ12,14-PGJ2is formed from PGD2by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50of 2 µM in a murine chimera system.1,215-deoxy-δ12,14-PGJ2is more potent than PGD2, δ12-PGJ2, and PGJ2in stimulating lipogenesis in C3H10T1/2 cells. The EC50for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1


1.Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5)803-812(1995) 2.Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al.A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiationCell83(5)813-819(1995)