您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 13(S)-HODE-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
13(S)-HODE-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
13(S)-HODE-d4图片
规格:98%
分子量:300.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
An internal standard for the quantification of 13-HODE
货号:ajcx21088
CAS:139408-39-2
分子式:C18H28D4O3
分子量:300.5
溶解度:DMF: >50 mg/ml (per Rao Maddipati),DMSO: >50 mg/ml (per Rao Maddipati),Ethanol: >50 mg/ml (per Rao Maddipati),PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

13(S)-HODE-d4contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC-or LC-mass spectrometry. 13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,1,2and down regulates the expression of the IRGpIIb/IIIa receptor.3


1.Buchanan, M.R., Haas, T.A., Lagarde, M., et al.13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOXThe Journal of Biological Chemisty26016056-16059(1985) 2.Honn, K.V., Nelson, K.K., Renaud, C., et al.Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasisProstaglandins44(5)413-429(1992) 3.Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al.Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acidCancer Res.49(4)1029-1037(1989)