AFP464是有活力的HIF-1α抑制剂,IC50值为0.25μM。同时也是arylhydrocarbonreceptor(AhR)的激活剂。
货号:ajcx13064
CAS:468719-52-0
分子式:C22H23F3N4O3
分子量：448.44
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AFP464, is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

[1]. Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70(17):6837-48.