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Quarfloxin(CX 3543)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quarfloxin(CX 3543)图片
规格:98%
分子量:604.67
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Quarfloxin(CX3543)是一种具有抗肿瘤活性的氟喹诺酮类衍生物,其靶向抑制RNApolI的活性,在神经母细胞瘤中的IC50值在纳摩尔级别。Quarfloxin干扰核糖体DNA中核蛋白与G-四重DNA结构的相互作用。
货号:ajcx12896
CAS:783364-52-3
分子式:C35H33FN6O3
分子量:604.67
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Quarfloxin (CX 3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].

Quarfloxin (CX 3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].


[1]. Hald ?H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.