| 规格: | 98% |
| 分子量: | 344.4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
Methyl α-Linolenyl Fluorophosphonate is an inhibitor of phospholipases.
Methyl α-linolenyl fluorophosphonate (MLnFP), an analog of methyl arachidonyl fluorophosphonate (MAFP), has not been completely investigated for its pharmacological activity.
In vitro: Methyl arachidonyl fluorophosphonate (MAFP) was reported to be a selective, active-site directed, irreversible inhibitor of cytosolic phospholipase A2 (cPLA2). MAFP could also potently inhibit the Ca2+-independent cytosolic phospholipase A2 (iPLA2) in a concentration-dependent manner. Such inhibition was not reversed upon extensive dilution of the enzyme into the assay mixture. Preincubation of iPLA2 with MAFP led to a linear and time-dependent inactivation of enzyme activity, and the enzyme was protected from inactivation by the reversible inhibitor. The ability of MAFP to inhibit the iPLA 2 indicated that this enzyme proceeded via an acyl-enzyme intermediate. Further testing showed that MAFP could not inhibit the CoA-dependent acyltransferase, arachidonoyI-CoA synthetase, or CoA-independent transacylase activities. Therefore, MAFP was not a general inhibitor for enzymes acting on arachidonoyi substrates [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
参考文献:
[1] Lio, Y. C.,Reynolds, L.J.,Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochimica et Biophysica Acta 1302, 55-60 (1996).
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