替莫唑胺酸是替莫唑胺的羧酸衍生物。替莫唑胺是一种 DNA 烷化剂，可甲基化 DNA 的鸟嘌呤和腺嘌呤碱基，导致 DNA 双链断裂、细胞周期停滞，并最终导致细胞死亡。替莫唑胺酸具有与母体化合物替莫唑胺相似的活性，具有相同的抗癌活性。
货号:ajcx28336
CAS:113942-30-6
分子式:C6H5N5O3
分子量：195.1
溶解度:DMF: 2 mg/ml,DMSO: 3 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Temozolomide acid is an active metabolite of the alkylating agent precursor temozolomide .¹It is cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner. Temozolomide acid is also a synthetic intermediate in the synthesis of temozolomide prodrugs with anticancer activity.²

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