PFM 01,N-烷基化 Mirin 衍生物,是一种 MRE11 核酸内切酶抑制剂。 PFM 01 可以通过非同源末端连接 (NHEJ) 与同源重组 (HR) 调节双链断裂修复 (DSBR)。
货号:ajcx27470
CAS:1558598-41-6
分子式:C14H15NO2S2
分子量:293.4
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:
现货Background:
MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.
Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID:24316220