A neuropeptide with diverse biological activities
货号:ajcx23690
CAS:N/A
分子式:C21H22D5NO3
分子量：346.5
溶解度:DMF: 17 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 13 mg/ml,Ethanol: 14 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UR-144 N-pentanoic acid metabolite-d₅contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of UR-144 N-pentanoic acid metabolite by GC-or LC-mass spectrometry (MS). UR-144 is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB₂receptor (K_i= 1.8 nM) over the central CB₁receptor (K_i= 150 nM).¹UR-144 N-pentanoic acid metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.^2,3This metabolite should be detectable in either serum or urine.^2,3The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.

1.Frost, J.M., Dart, M.J., Tietje, K.R., et al.Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activityJ. Med. Chem.53(1)295-315(2010) 2.Wintermeyer, A., MÖller, I., Thevis, M., et al.In vitro phase I metabolism of the synthetic cannabimimetic JWH-018Anal. Bioanal. Chem.398(5)2141-2153(2010) 3.Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., et al.Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urineAnal. Chem.83(16)6381-6388(2011)