A neuropeptide with diverse biological activities
货号:ajcx21068
CAS:N/A
分子式:C20H30D4O5
分子量：358.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

11β-13,14-dihydro-15-keto Prostaglandin F_2α-d₄(11β-13,14-dihydro-15-keto PGF_2α-d₄) is intended for use as an internal standard for the quantification of 11β-13,14-dihydro-15-keto PGF_2αby GC- or LC-MS. 11β-13,14-dihydro-15-keto PGF_2αis a metabolite of PGD₂in the 15-hydroxy PGDH pathway.^1,2Infusion or inhalation of tritiated PGD₂in normal males results in the appearance of peak levels of both 11β-PGF_2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF_2αin the plasma within 10 minutes.¹Homogenates of human lung metabolize PGD₂first to 11β-PGF_2αand then to 11β-15-keto PGF_2αin the presence of NAD⁺, but not 11β-13,14-dihydro-15-keto PGF_2α.²Guinea pig liver and kidney homogenates metabolize PGD₂to 11β-13,14-dihydro-15-keto PGF_2α,via11β-PGF_2α, in the presence of NAD⁺and NADP⁺.²

1.Robinson, C., Hardy, C.C., and Holgate, S.T.The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal menBiochim. Biophys. Acta963(2)151-161(1988) 2.Robinson, C., Herbert, C.A., Bedwell, S., et al.The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathwaysBiochem. Pharmacol.38(19)3267-3271(1989)