Lenalidomide-C5-amido-Boc 是一种基于 Lenalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Lenalidomide-C5-amido-Boc 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。
货号:ajcx35752
CAS:2138441-25-3
分子式:C23H31N3O5
分子量：429.51
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].

[1]. Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12.
[2]. Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.