您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > PQ 69
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PQ 69
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PQ 69图片
规格:98%
分子量:350.39
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
PQ 69 是一种有效的选择性腺苷 A1 受体拮抗剂,具有反向激动剂活性。
货号:ajcx27016
CAS:910045-32-8
分子式:C20H19FN4O
分子量:350.39
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.


Lu et al (2014) PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 10 619 PMID:25248972