Arbutin-d4 是氘标记的熊果苷。 Arbutin (β-Arbutin) 是黑色素细胞中酪氨酸酶的竞争性抑制剂，单酚酶的 Kiapp 值为 1.42 mM；双酚酶为 0.9 mM。熊果苷也用作脱色剂。熊果苷是从熊果植物 Arctostaphylos uvaursi 中分离出来的一种天然多酚，具有抗氧化、抗炎和抗肿瘤的特性。
货号:ajcx24696
CAS:N/A
分子式:C12H12D4O7
分子量：276.3
溶解度:Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Arbutin-d₄is intended for use as an internal standard for the quantification of arbutin by GC- or LC-MS. Arbutin is a glycosylated hydroquinone that has been found inArctostaphylosplants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties.^1,2It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC₅₀s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC₅₀= 0.5 mM).³Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM.²In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum.⁴Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.

1.Seo, D.-H., Jung, J.-H., Lee, J.-E., et al.Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivativesAppl. Microbiol. Biotechnol.95(6)1417-1425(2012) 2.Takebayashi, J., Ishii, R., Chen, J., et al.Reassessment of antioxidant activity of arbutin: Multifaceted evaluation using five antioxidant assay systemsFree Radic. Res.44(4)473-478(2010) 3.Maeda, K., and Fukuda, M.Arbutin: Mechanism of its depigmenting action in human melanocyte cultureJ. Pharmacol. Exp. Ther.276(2)765-769(1996) 4.Ye, J., Guan, M., Lu, Y., et al.Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathwayPulm. Pharmacol. Ther.5453-59(2019)