多杀菌素是一种多杀菌素 A 和 D 的混合物，被称为土壤放线菌 (Saccharopolyspora spinosa) 的发酵产物，是一种具有更广泛作用谱的生物神经毒性杀虫剂。
货号:ajcx23500
CAS:168316-95-8
分子式:C83H132N2O20
分子量：1478
溶解度:Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Spinosad is a naturally-occurring insecticide found in the the soil bacteriumS. spinosa.¹It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D , which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies includingC. capitata, B. curcurbitae, andB. dorsalis(LC₅₀s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 µg/ml, respectively) but has low toxicity in vertebrates.^2,3,4It also inhibits canine P-glycoprotein (P-gp; IC₅₀= 0.2 µg/ml).⁵Formulations containing spinosad have been used in the agricultural and veterinary control of insects.

1.Vo, D.T., Hsu, W.H., Abu-Basha, E.A., et al.Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animalsJ. Vet. Pharmacol. Ther.33(4)315-322(2010) 2.Stark, J.D., Vargas, R., and Miller, N.Toxicity of spinosad in protein bait to three economically important tephritid fruit fly species (Diptera: Tephritidae) and their parasitoids (Hymenoptera: Braconidae).J. Econ. Entomol.97(3)911-915(2004) 3.SÁnchez-Bayo, F.Insecticides mode of action in relation to their toxicity to non-target organismsJ. Environ. Anal. Toxicol.S4:002(2012) 4.Amaral, T.S., Carvalho, T.F., Silva, M.C., et al.Short-term effects of a spinosyn's family insecticide on energy metabolism and liver morphology in frugivorous bats Artibeus lituratus (Olfers, 1818)Braz. J. Biol.72(2)299-304(2012) 5.Schrickx, J.A.Spinosad is a potent inhibitor of canine P-glycoproteinVet. J.200(1)195-196(2014)