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Arachidonoyl Glycine-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arachidonoyl Glycine-d8图片
规格:98%
分子量:369.6
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of arachidonoyl glycine
货号:ajcx21714
CAS:1159908-44-7
分子式:C22H27D8NO3
分子量:369.6
溶解度:DMF: 20 mg/ml,DMSO: 15 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 2 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Arachidonoyl glycine-d8(NAGly-d8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of NAGly by GC-or LC-mass spectrometry. NAGly has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA),1from extracts of mammalian brain,2,3and has also been synthesized as an analog of AEA for structure/activity testing.4NAGly may be produced endogenouslyviaoxidation of AEA, or by transacylation of arachidonoyl coenzyme A. NAGly is reported to have analgesic activities in whole animal experiments.1,2,3Since it seems to be a very poor ligand for the CB1receptor,4these effects are probably mediatedviaother signalling pathways.


1.Burstein, S.H., Rossetti, R.G., Yagen, B., et al.Oxidative metabolism of anandamideProstaglandins & Other Lipid Mediators6129-41(2000) 2.Huang, S.M., Bisogno, T., Petros, T.J., et al.Identification and characterization of an endogenous anandamide-like compound: N-arachidonylglycine (NAGly)ICRS 2001 Symposium on the Cannabinoids78(2001) 3.Huang, S.M., Bisogno, T., Petros, T.J., et al.Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits painThe Journal of Biological Chemisty276(46)42639-42644(2001) 4.Sheskin, T., Hanus, L., Slager, J., et al.Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptorJournal of Medicinal Chemistry40659-667(1997)