Midostaurin-D5(PKC412-D5)是Midostaurin的氘代化合物。Midostaurin是一种多靶点蛋白激酶抑制剂，抑制PKCα/β/γ，Syk，Flk-1，Akt，PKA，c-Kit，c-Fgr，c-Src，FLT3，PDFRβ和VEGFR1/2的活性，IC50值为22-500nM。
货号:ajcx31066
CAS:N/A
分子式:C35H25D5N4O4
分子量：575.67
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Midostaurin-D5 (PKC412-D5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

[1]. Fabbro D, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82(2-3):293-301.