Gossypin是从Hibiscusvitifolius中分离得到的一种黄酮，具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病、镇痛和保护肝脏的活性。Gossypin抑制NF-κB和NF-κB的调节基因表达。在小鼠原代骨髓细胞和RAW264.7细胞中，Gossypin也可抑制RANKL诱导的破骨细胞形成。
货号:ajcx29372
CAS:652-78-8
分子式:C21H20O13
分子量：480.38
溶解度:30 mg/ml in DMF,PBS (pH 7.2) (1:2): 0.3 mg/ml in DMF,25 mg/ml in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, analgesic and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].

[1]. Ajaikumar B Kunnumakkara, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21. [2]. Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.