T-1095 是一种选择性和口服活性的 Na+-葡萄糖协同转运蛋白 (SGLT) 抑制剂，对人 SGLT1 和 SGLT2 的 IC50 分别为 22.8 μM 和 2.3 μM。
货号:ajcx28428
CAS:209746-59-8
分子式:C26H28O11
分子量：516.5
溶解度:DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

T-1095 is an inhibitor of sodium-glucose cotransporter 1 (SGLT1) and SGLT2 (IC₅₀s = 22.8 and 2.3 µM, respectively).¹Dietary administration of T-1095 (0.01% w/w) reduces blood glucose and HbA1c levels in a rat model of diabetes induced by streptozotocin . It suppresses the development of hyperglycemia and hypertriglyceridemia and reduces HbA1c levels in the KKAγ mouse model of type 2 diabetes. T-1095 exacerbates post-infarction cardiac dysfunction in a rat model of left anterior descending coronary artery ligation-induced myocardial infarction.²

1.Oku, A., Ueta, K., Ishihara, T., et al.T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetesDiabetes48(9)1794-1800(1999) 2.Bruno, J.G., Herman, T.S., Cano, V.L., et al.Selective cytotoxicity of 3-amino-L-tyrosine correlates with peroxidase activityIn Vitro Cell. Dev. Biol. Anim.35(7)376-382(1999)