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STAD 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
STAD 2图片
包装:500ug
规格:98%
市场价:7044元
分子量:2096.68

产品介绍
STAD 2 是 PKA-RII 的有效选择性破坏剂,Kd 为 6.2 nM。
货号:ajcx27684
CAS:1542100-77-5
分子式:C102H182N24O22
分子量:2096.68
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.


Bendzunas et al (2018) Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 26 1174 PMID:29449124 |Flaherty et al (2015) The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 10 e0129239 PMID:26010880 |Wang et al (2014) Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 9 635 PMID:24422448