阿巴芬净是一种抗真菌剂，可抑制甾醇侧链 C-24 位点的甲基转移，由甾醇-C-24-甲基转移酶催化。
货号:ajcx26458
CAS:129639-79-8
分子式:C21H22N4OS
分子量：378.5
溶解度:DMF: 10 mg/mL,DMSO: 2.5 mg/mL,Ethanol: 0.3 mg/mL,PBS (pH 7.2): 0.3 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Abafungin is an antifungal agent.¹It is active against a variety of dermatophytes, yeast, molds, and other fungi (MICs = ≤0.06-2, 0.5-16, ≤0.06-1, and 0.25-8 µg/ml, respectively). Abafungin inhibits ergosterol biosynthesis, as well as acts directly on the fungal cell membrane to induce cell death.

1.Borelli, C., Schaller, M., Niewerth, M., et al.Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungiChemotherapy54(4)245-259(2022)