A ROCK2 inhibitor
货号:ajcx25628
CAS:N/A
分子式:C24H28N4O4·2HCl [XH2O]
分子量：527.4
溶解度:DMSO: 100 mM,Water: 5 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC₅₀=<1 nm).¹It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC₅₀s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC₅₀=<4 nM).

1.Chen, Y.T., Vojkovsky, T., Fang, X., et al.Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitorsMed. Chem. Commun.2(1)73-75(2011)