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Sulindac-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulindac-d3图片
规格:98%
分子量:359.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
C20H14D3FO3S
货号:ajcx24446
CAS:N/A
分子式:C20H14D3FO3S
分子量:359.4
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Sulindac-d3is intended for use as an internal standard for the quantification of sulindac by GC- or LC-MS. Sulindac is a non-steroidal anti-inflammatory drug (NSAID), selective COX-2 inhibitor (IC50s = 0.79 and >1,000 µM for COX-2 and COX-1, respectively), and prodrug form of sulindac sulfide .1,2,3,4Sulindac is reduced by intestinal bacteria to form sulindac sulfide.1It inhibits acetic acid-induced writhing in mice and reduces paw edema induced by carrageenan in rats when administered at a dose of 100 mg/kg.3Sulindac (60 mg/kg) reduces tumor growth in MiaPaCa-2 and BxPC-3 mouse xenograft models.4Formulations containing sulindac have been used in the treatment of pain associated with arthritis, ankylosing spondylitis, and gout.


1.Maseda, D., and Ricciotti, E.NSAID-gut microbiota interactionsFront. Pharmacol.111153(2020) 2.Grossman, C.J., Wiseman, J., Lucas, F.S., et al.Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitorsInflamm. Res.44(6)253-257(1995) 3.Bhat, M.A., Al-Omar, M.A., Alsaif, N.A., et al.Novel sulindac derivatives: Synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activityJ. Enzyme Inhib. Med. Chem.35(1)921-934(2020) 4.Yip-Schneider, M.T., Wu, H., Ralstin, M., et al.Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivoMol. Cancer Ther.6(6)1736-1744(2007)