A neuropeptide with diverse biological activities
货号:ajcx23688
CAS:N/A
分子式:C21H24D5NO2
分子量：332.5
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UR-144 N-(5-hydroxypentyl) metabolite-d₅is intended for use as an internal standard for the quantification of UR-144 N-(5-hydroxypentyl) metabolite by GC-or LC-MS. UR-144 is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB₂receptor (K_i= 1.8 nM) over the central CB₁receptor (K_i= 150 nM).¹UR-144 N-(5-hydroxypentyl) metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.^2,3This metabolite should be detectable in either serum or urine. The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.

1.Frost, J.M., Dart, M.J., Tietje, K.R., et al.Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activityJ. Med. Chem.53(1)295-315(2010) 2.Wintermeyer, A., MÖller, I., Thevis, M., et al.In vitro phase I metabolism of the synthetic cannabimimetic JWH-018Anal. Bioanal. Chem.398(5)2141-2153(2010) 3.Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., et al.Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urineAnal. Chem.83(16)6381-6388(2011)