A neuropeptide with diverse biological activities
货号:ajcx22742
CAS:N/A
分子式:C21H17D5ClNO2
分子量：360.9
溶解度:DMF: 10 mg/ml,DMSO: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JWH 203 N-(4-hydroxypentyl) metabolite-d₅contains five deuterium atoms at the 2, 4 ,5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 203 N-(4-hydroxypentyl) metabolite by GC-or LC-mass spectrometry. JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as an agonist with K_ivalues of 8.0 and 7.0 nM at the central cannabinoid (CB₁) and peripheral (CB₂) receptors, respectively.¹Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB₁and CB₂receptors (JWH 250 K_is = 11 and 33 nM, respectively).¹JWH 203 N-(4-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.^2,3This product is intended for research and forensic applications.

1.Huffman, J.W., Szklennik, P.V., Almond, A., et al.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indolesBioorg. Med. Chem. Lett.15(18)4110-4113(2005) 2.Brents, L.K., Reichard, E.E., Zimmerman, M., et al.Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activityPLoS One6(7)1-9(2011) 3.Brents, L.K., Gallus-Zawala, A., Radominska-Pandya, A., et al.Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retainintermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutralantagonist to partial agonist activityBiochemical Pharmacology83952-961(2012)