A tobacco-specific nitrosamine carcinogen
货号:ajcx21364
CAS:64091-91-4
分子式:C10H13N3O2
分子量：207.2
溶解度:DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml,
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific nitrosamine carcinogen.¹Reactive metabolites of NNK alkylate DNA, forming pyridyloxobutyl (POB) and pyridylhydroxybutyl (PHB) adducts, and induce DNA methylation. NNK (100 mg/kg, single dose) increases the protein levels of DNA methyltransferase 1 (DNMT1) in mouse bronchial epithelial cells within one day and increases hypermethylation of the tumor suppressor genesChd13,Prdm2, andRunx3in lung tissue within three days.²It induces tumor formation preferentially in the lungviavarious routes of administration in animal models.³NNK induces adenomas and adenocarcinomas, which are present after 16 and 50 weeks, respectively, in mouse lung when administered at a single dose of 10 &#181mol/animal. Lifetime administration of NNK (63.5 mg/animal) to rats results in a 90% incidence of lung tumors.⁴

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