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Indacaterol-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indacaterol-d3图片
包装:1mg
规格:98%
市场价:5556元
分子量:395.5

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx20092
CAS:2699828-16-3
分子式:C24H25D3N2O3
分子量:395.5
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Indacaterol-d3 is intended for use as an internal standard for the quantification of indacaterol by GC- or LC-MS. Indacaterol is a long-acting and selective β2-adrenergic receptor (β2-AR) agonist (EC50 = 8.71 nM for increasing intracellular cAMP levels in vitro).1 It is selective for β2-ARs over β1- and β3-ARs (Kis = 43.6, 616.6, and 3,311.3 nM, respectively). Indacaterol inhibits bronchoconstriction induced by serotonin in conscious guinea pigs with a maximal effect of 85% when administered intratracheally at a dose of 6.7 μg/kg. It also inhibits bronchoconstriction induced by methacholine in rhesus monkeys with a maximal effect of 75% when administered via nebulization at a dose of 12.5 mg/kg. Formulations containing indacaterol have been used alone, and in combination with glycopyrrolate, in the treatment of chronic obstructive pulmonary disease.


|1. Battram, C., Charlton, S.J., Cuenoud, B., et al. In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled β2 adrenoceptor agonist with a 24-h duration of action. J. Pharmacol. Exp. Ther. 317(2), 762-770 (2006).