C111H197N43O29S.XCF3COOH
货号:ajcx19482
CAS:N/A
分子式:C111H197N43O29S.XCF3COOH
分子量：2630.1
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Histone H4R3Me2s (1-21)-GGK-biotin is a peptide fragment of histone H4 that corresponds to amino acid residues 2-22 of the human H4 sequence. It is symmetrically dimethylated at arginine 3 and biotinylated via a C-terminal GGK linker. Symmetric dimethylation of histone 4 at arginine 3 is associated with transcriptional repression.1 It can recruit the DNA methyltransferase DNMT3a, leading to DNA methylation and further transcriptional repression. Histone H4R3Me2s (1-21)-GGK-biotin has been used as a substrate for the qualitative measurement of jumonji domain containing 1B (JMJD1B) arginine demethylase activity and in dot blot assays to verify antibody specificity.2

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