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N-(5-Hydroxypentyl)maleimide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-(5-Hydroxypentyl)maleimide图片
规格:98%
分子量:183.2
包装与价格:
包装价格(元)
100mg电议
500mg电议
1g电议

产品介绍
N-(5-Hydroxypentyl)maleimide是一种不可降解(non-cleavable)的ADClinker,可用于合成抗体偶联药物(ADC),例如Gemcitabine-O-Si(di-iso)-O-Mc。
货号:ajcx31136
CAS:180608-78-0
分子式:C9H13NO3
分子量:183.2
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc )[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].


[1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody-drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.