N-(5-Hydroxypentyl)maleimide是一种不可降解(non-cleavable)的ADClinker，可用于合成抗体偶联药物(ADC)，例如Gemcitabine-O-Si(di-iso)-O-Mc。
货号:ajcx31136
CAS:180608-78-0
分子式:C9H13NO3
分子量：183.2
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc )[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].

[1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody-drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.