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Tenofovir diphosphate triethylamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenofovir diphosphate triethylamine图片
包装:1mg
规格:98%
市场价:10319元
分子量:548.36

产品介绍
Tenofovirdiphosphatetriethylamine(TFV-DPtriethylamine)是一种ATP竞争性的DNA聚合酶(DNApolymerases)抑制剂,且是1型HIV(HIV-1)逆转录酶(RT)的底物。
货号:ajcx29722
CAS:2122333-63-3
分子式:C15H31N6O10P3
分子量:548.36
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].

Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ?, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1].


[1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.